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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP2CA
All Species:
50.91
Human Site:
T53
Identified Species:
74.67
UniProt:
P67775
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P67775
NP_002706.1
309
35594
T53
Q
E
V
R
C
P
V
T
V
C
G
D
V
H
G
Chimpanzee
Pan troglodytes
XP_527011
309
35630
T53
Q
E
V
R
C
P
V
T
V
C
G
D
V
H
G
Rhesus Macaque
Macaca mulatta
XP_001084083
286
32771
R49
E
S
N
V
Q
E
V
R
C
P
V
T
V
C
G
Dog
Lupus familis
XP_858531
311
35711
T53
Q
E
V
R
C
P
V
T
V
C
G
D
V
H
G
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
P63331
309
35590
T53
Q
E
V
R
C
P
V
T
V
C
G
D
V
H
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512852
302
34248
G53
T
V
C
G
D
V
H
G
Q
F
H
D
L
M
E
Chicken
Gallus gallus
P48463
309
35545
T53
Q
E
V
R
C
P
V
T
V
C
G
D
V
H
G
Frog
Xenopus laevis
Q6IP91
307
35104
G57
T
V
C
G
D
I
H
G
Q
F
Y
D
L
K
E
Zebra Danio
Brachydanio rerio
A8WGP3
311
35438
T54
Q
S
V
D
S
P
V
T
V
C
G
D
I
H
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23696
309
35450
T53
Q
E
V
K
C
P
V
T
V
C
G
D
V
H
G
Honey Bee
Apis mellifera
XP_623105
309
35425
T53
Q
E
V
K
C
P
V
T
V
C
G
D
V
H
G
Nematode Worm
Caenorhab. elegans
Q9XW79
333
37341
T75
Q
V
I
D
S
P
V
T
I
C
G
D
I
H
G
Sea Urchin
Strong. purpuratus
XP_780423
308
35412
T52
Q
E
V
K
C
P
V
T
V
C
G
D
V
H
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q07100
313
35814
T57
Q
P
V
K
S
P
V
T
I
C
G
D
I
H
G
Baker's Yeast
Sacchar. cerevisiae
P23595
377
43028
T121
K
P
I
N
V
P
V
T
I
C
G
D
V
H
G
Red Bread Mold
Neurospora crassa
P48580
327
37273
T71
Q
P
V
K
C
P
V
T
V
C
G
D
I
H
G
Conservation
Percent
Protein Identity:
100
99
89.9
96.7
N.A.
N.A.
99.6
N.A.
90.9
98
66
64.6
N.A.
93.8
96.1
59.1
93.5
Protein Similarity:
100
99
91.9
98.7
N.A.
N.A.
100
N.A.
93.1
99
81.5
81
N.A.
98.7
98
74.7
96.7
P-Site Identity:
100
100
20
100
N.A.
N.A.
100
N.A.
6.6
100
6.6
73.3
N.A.
93.3
93.3
60
93.3
P-Site Similarity:
100
100
26.6
100
N.A.
N.A.
100
N.A.
13.3
100
13.3
80
N.A.
100
100
80
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
78.5
62.6
81.3
Protein Similarity:
N.A.
N.A.
N.A.
87.2
71.8
86.8
P-Site Identity:
N.A.
N.A.
N.A.
66.6
60
80
P-Site Similarity:
N.A.
N.A.
N.A.
86.6
80
93.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
13
0
57
0
0
0
7
82
0
0
0
7
0
% C
% Asp:
0
0
0
13
13
0
0
0
0
0
0
94
0
0
0
% D
% Glu:
7
50
0
0
0
7
0
0
0
0
0
0
0
0
13
% E
% Phe:
0
0
0
0
0
0
0
0
0
13
0
0
0
0
0
% F
% Gly:
0
0
0
13
0
0
0
13
0
0
82
0
0
0
88
% G
% His:
0
0
0
0
0
0
13
0
0
0
7
0
0
82
0
% H
% Ile:
0
0
13
0
0
7
0
0
19
0
0
0
25
0
0
% I
% Lys:
7
0
0
32
0
0
0
0
0
0
0
0
0
7
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
7
7
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
19
0
0
0
82
0
0
0
7
0
0
0
0
0
% P
% Gln:
75
0
0
0
7
0
0
0
13
0
0
0
0
0
0
% Q
% Arg:
0
0
0
32
0
0
0
7
0
0
0
0
0
0
0
% R
% Ser:
0
13
0
0
19
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
13
0
0
0
0
0
0
82
0
0
0
7
0
0
0
% T
% Val:
0
19
69
7
7
7
88
0
63
0
7
0
63
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _